The tics were obtained using the dedicated siemens software for dynamic. It is most commonly found in the major salivary glands parotid but may also present in the minor salivary glands. Skin nonmelanocytic tumors mucoepidermoid carcinoma. Interest of diffusionweighted and gadoliniumenhanced dynamic.
A 14yearold boy with an unremarkable medical history developed a slowly growing mass in the region of the left parotid gland. After 4 months, extirpation of the mass was done and the. It is well known that mucoepidermoid carcinoma mec displays a variety of biological behaviors. Salivary gland carcinomas are a clinically diverse group of neoplasms with histological patterns overlapping other tumors, thus complicating their diagnosis. It can mimic most other tumors of the glands, and therefore is often considered. To determine the diagnostic accuracy of fineneedle aspiration fna and imaging modalities for lowgrade mucoepidermoid carcinoma mec of the parotid gland. Mucoepidermoid carcinoma genetic and rare diseases. It can mimic most other tumors of the glands, and therefore is often considered in the differential. One hundred fortynine consecutive patients with suspected tumors of the parotid gland were examined with an epidwi sequence by using a 1. Notably, binder et al cited the misclassification of highgrade mucoepidermoid carcinomas as adenosquamous carcinomas. Nov 29, 2014 salivary gland carcinomas are a clinically diverse group of neoplasms with histological patterns overlapping other tumors, thus complicating their diagnosis. Sensitivity of fineneedle aspiration and imaging modalities. Circumscribed tumor, may not be attached to surface multilobulated nodulocystic tumor extending throughout dermis, exhibiting glandular and squamoid differentiation. This is a patient with surgical stage t1, clinical n0, lowgrade parotid mucoepidermoid carcinoma.
Jul 15, 2015 lowgrade mec tends to have an excellent prognosis, although recurrence of the disease is possible. Introduction saliva is a clear, alkaline, somewhat viscid secretion from the parotid, submandibular, sublingual and smaller mucous glands of the mouth. Accuracy of diagnosis of salivary gland tumors with the use of. Mucoepidermoid carcinoma mec is a malignant epithelial neoplasm composed of varying proportions of mucous, epidermoid, intermediate, columnar, and clear cells and often demonstrates prominent cystic growth.
Mucoepidermoid carcinoma of the salivary gland is one of the differential diagnoses. Dec 27, 2015 mucoepidermoid carcinoma epidemiology. Using paclitaxel taxol, another antimicrotubule drug, alone has had moderate activity against mucoepidermoid tumors and adenocarcinomas but no effect adenoid cystic carcinoma. Ask the experts mucoepidermoid carcinoma of the parotid. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac, and thyroid gland. Accuracy assessment of combined diffusion weighed and dynamic. They develop less often in the submandibular glands or in minor salivary glands inside the mouth. Mucoepidermoid carcinoma of salivary glands radiology.
Nov 29, 2018 human cytomegalovirus and mucoepidermoid carcinoma of salivary glands. Mucoepidermoid carcinoma the salivary glands are those glands whose primary function is to produce saliva. Ask the experts mucoepidermoid carcinoma of the parotid gland. D, postcontrast t1weighted image of the illdefined mucoepidermoid carcinoma arrows. Accuracy of diagnosis of salivary gland tumors with the use. In the face of small, lowgrade cancers, the risk of lymph. While the highgrade type is a highly aggressive tumor, its lowgrade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm. Underlying histopathology was of adenoid cystic carcinoma. June 16, 2017 035 imaging is required when there is larger and deeper tumors with limited mobility andor suspected malignancy. Meca mucoepidermoid carcinoma most frequently arises in and is the most common primary malignant tumor of the parotid gland, typically affecting adults ages 35 to 65 years but also occurring in children as the most common malignant salivary gland tumor of childhood initial presentation is usually painless swelling. Recurrent mucoepidermoid carcinoma of parotid with facial. A and b lowgrade mucoepidermoid carcinoma of left parotid. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Mucoepidermoid carcinoma in adults mostly develops between the third and fourth decades, with an equal sex distribution.
Of the malignant tumors, the most common are mucoepidermoid carcinoma, adenoid cystic carcinoma, and squamous cell carcinoma. Salivary gland cancer treatment options include surgery with or without postoperative radiation therapy, radiation therapy, and chemotherapy. Mucoepidermoid carcinoma mec of the salivary gland is believed to arise from pluripotent reserve cells of the excretory ducts that are capable of differentiating into squamous, columnar, and mucous cells. Data were fed to the computer and analyzed using ibm spss software package version 20 2. Cords, sheets and clusters of mucous, squamous, intermediate and clear cells. All statistical analyses were performed using spss software version 12. Mucoepidermoid carcinoma what is, treatment, survival. Mucoepidermoid carcinoma mec is a malignant salivary gland neoplasm with extreme morphologic heterogeneity and hence rendering a definitive fine needle aspiration cytology fnac diagnosis of.
Mucoepidermoid carcinoma of the soft palate salivary gland. More than half of these cases involve the major salivary glands, primarily the parotid glands. The spss software package was used for the analysis. Mucoepidermoid carcinomas are the most common type of salivary gland cancer. Mucoepidermoid carcinoma, salivary gland neoplasms.
Cytological diagnosis of mucoepidermoid carcinoma of parotid. Our aim was to determine the value of echoplanar diffusionweighted mr imaging epidwi in differentiating various types of primary parotid gland tumors. There are some reports of mec with unusual distant metastases 2. Mucoepidermoid carcinoma, abbreviated mec, the is the most common malignant neoplasm of the salivary gland. Mri findings of mucoepidermois carcinoma of the parotid gland. Both computed tomography ct and magnetic resonance imaging mri are complementary to each other. Dec 01, 2005 mucoepidermoid carcinoma mec is the most common primary salivary gland malignancy, accounting for approximately 25% of all malignancies. Although ultrasound is the firstline imaging tool for salivary gland. This is a case of a young boy with lowgrade mucoepidermoid carcinoma treated with superficial parotidectomy, resulting in positive margins. Jul 21, 20 mucoepidermoid carcinoma mec, one of the most common salivary gland malignancies, is rare in children. Epidemiology mucoepidermoid carcinomas are seen throughout all. Parotid gland tumor pathology is complex, as it includes a variety of different.
One cm hypoechoic mass was seen in the subcutaneous tissue of the left cheek, which indicates a residual mass or postoperative fibrosis. The histopathology revealed mucoepidermoid carcinoma of low grade. Cancer in the salivary gland is called salivary gland cancer. Clinical, histological, and radiological findings of palatal mec in a 12yearold girl are presented with threeyear followup. Mucoepidermoid carcinoma of parotid gland salman a. Mri findings of mucoepidermois carcinoma of the parotid. Mucoepidermoid carcinoma is a tumor that usually occurs in the salivary glands. Contrastenhanced multidetector ct examination of parotid gland. Mar 19, 2019 parotid tumors are the most common of the salivary gland tumors, constituting 80% of all salivary gland tumors.
Mucoepidermoid carcinoma an overview sciencedirect topics. The parotid gland 50% is the most common location for mc followed by the palate 45% and submandibular gland. These cancers are usually low grade, but they can also be intermediate or high grade. Original article prognostic factors in mucoepidermoid. Mar 18, 2019 using a platinumbased agent, cisplatin, and an antimicrotubule drug, docetaxel, with radiation shows some promise in advanced carcinomas of the salivary gland. Mucoepidermoid carcinoma mc is the most common malignant tumor of the parotid gland and accounts for 44% of all parotid gland malignancies. Postoperative radiation therapy for parotid mucoepidermoid.
Mucoepidermoid carcinoma the oral cancer foundation. Diffusionweighted echoplanar mr imaging of primary parotid. Mucoepidermoid carcinoma with distant metastases to the. The most common benign sgts are pleomorphic adenoma, adenolymphoma, basal cell adenoma, oxyphilic adenoma, myoepithelioma, and papillary cystadenoma.
Objective to determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. A 68yearold man with mucoepidermoid carcinoma of sublingual gland. Management of mucoepidermoid carcinoma of the palate. Adjuvant treatment for parotid mucoepidermoid carcinoma. Mucoepidermoid carcinoma mec, first described by masson and berger in 1924, is a wellrecognized salivary gland neoplasm, accounting for 510% of all salivary gland tumors. Mucoepidermoid carcinoma with distant metastases to the kidney, adrenal gland, skull and gluteus maximus muscle. Conventional mri imaging of these lesions had shown some suggestive.
Postoperative radiotherapy for mucoepidermoid carcinoma of the. Mec can also involve a variety of other sites that have minor mucoserous glands. The number of individuals diagnosed with cancer is increasing. Get detailed information about the treatment for newly diagnosed and recurrent salivary gland cancer in this summary for clinicians. Apparent diffusion coefficient mapping of salivary gland tumors. The most common malignant salivary gland tumors include adenoid cystic carcinoma acc, mucoepidermoid carcinoma, secretory carcinomas, acinic cell carcinoma, and various adenocarcinoma histologies, including salivary ductal carcinoma. Mucoepidermoid carcinoma is often associated with tobacco smoking.
I did have an unrelated tumor type on my left clavicle at age 20, but have been cancerfree since 1981. Mucoepidermoid carcinoma has a major impact on society all over the world. Salivary gland neoplasms account for approximately 5% of head and neck neoplasms, but fewer than 1% of malig. Pdf cytological diagnosis of mucoepidermoid carcinoma of.
Their most favoured site is the parotid gland, which accounts for over 80% of mecs 14. Mucoepidermoid carcinoma mec is the most common malignancy of the salivary gland, accounting for 315% of all salivary gland tumours. Salivary gland tumors account for only 3% of all tumors in the body and it is estimated. Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Histologically, mec has been classified as low, intermediate or high grade according to intracystic components. Salivary gland cancers are rare and represent approximately 5% of all head and neck cancers and only 0. Mar 25, 2006 hey marc, hope all went well with your surgery. Mec mainly occurs in the parotid gland, along with minor glands being the second common site, particularly in palate. This video clipping shows exision of mucoepidermoid carcinoma of parotid gland. Ct is recommended, as it is an effective imaging tool for differential diagnosis in. Repeated ultrasound showed normal echogenicity of the left parotid gland and no discrete nodule seen. Before merging raw data into the software, the likelihood ratio i2 index and. Mucoepidermoid carcinoma in a minor salivary gland in a child. I had a mucoepidermoid carcinoma of the parotid at age 17 in 1978.
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